## Reweighting and enhanced sampling techniques If some data get generated at distribution $P(x)$, and another set get generated on $P'(x)$, we wanna extract information of $P(x)$ from $P'(x)$ samples. This is the goal of enhanced sampling techniques, and may be achieved by reweighting. >[!Note] >By "enhanced sampling techniques", one assigns higher probability to those hard-to-reach regions, to get more samples, and recover real landscape based on the probability profile. Some enhanced sampling techniques: - [Metadynamics](https://en.wikipedia.org/wiki/Metadynamics) - [Umbrella sampling](https://en.wikipedia.org/wiki/Umbrella_sampling) - [Replica exchange molecular dynamics](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484850/) - [Accelerated molecular dynamics](https://ambermd.org/tutorials/advanced/tutorial22/) >[!Info] >See similar chapters: [[Data representation]], [[Landmarks]], [[Dimensionality reduction]].